What Is DSIP Peptide?
DSIP stands for delta sleep-inducing peptide. It is a nonapeptide, nine amino acids long, with the sequence Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu. It was isolated in 1977 by Swiss researchers Schoenenberger and Monnier, who took blood from rabbits in which sleep had been induced by electrical stimulation of the brain, transferred it to other rabbits, and recorded more delta waves, the slow brain waves of deep sleep, in the recipients. The peptide responsible was named after that effect.
DSIP has since been found in the brain, in peripheral tissues and in blood plasma, in humans as well as animals. What has not been found, despite decades of work, is a dedicated DSIP receptor or a gene that clearly codes for it, which is part of what keeps the delta sleep inducing peptide interesting to researchers.
What Does DSIP Do? How DSIP Works in Research
DSIP is studied across several systems, and the research picture is more varied than its name suggests:
- Sleep architecture. The original work, and much that followed, examined DSIP's effect on slow-wave sleep in animals. Small human studies in the 1980s produced mixed results, and the sleep effect remains debated.
- Stress responses. Research reports that DSIP modulates stress-related hormone signalling and has been examined in animal models of stress.
- Neuromodulation. Studies suggest DSIP interacts with several neurotransmitter systems rather than acting through one receptor, which may explain why its effects vary between models.
- Antioxidant activity. Some papers examine protective effects against oxidative stress in cells and tissues.
Browse the published work, with links to each paper, in our DSIP research library.
DSIP 5mg and 10mg Vials
Chainwell Peptide stocks DSIP in two vial fills, both produced to the same specification and sealed in the same 3 mL glass vial with a teal flip-off cap, the colour we use across our sleep and longevity research peptides. Choose the size that matches the scale of your study.
DSIP 5mg
The DSIP 5mg vial is the smaller format, suited to a first order, method development or a short study where you want to try DSIP before committing to more material. It is also the easiest fill to use completely inside the 28 day window after reconstitution, so little peptide is lost if a study pauses.
For DSIP 5mg reconstitution, 1 mL of bacteriostatic water gives 5mg per mL and 2 mL gives 2.5mg per mL.
DSIP 10mg
DSIP 10mg carries twice the peptide of the 5mg vial in a single lot, so ongoing work runs from one certificate of analysis rather than two, and it costs less per milligram. It suits labs that already work with DSIP and have a settled method.
For the 10mg vial, 2 mL of bacteriostatic water gives 5mg per mL, the same concentration as 1 mL in the 5mg vial. Choose it when you are confident the reconstituted vial will be used within 28 days.
DSIP Reconstitution and Storage
To reconstitute DSIP, let the vial reach room temperature, wipe the stopper with an alcohol swab, and add bacteriostatic water slowly down the inside wall with a U-100 insulin syringe. Swirl gently until clear; do not shake. Our reconstitution guide and calculator works out any other volume.
Does DSIP need to be refrigerated? Once reconstituted, yes: keep it at 2 to 8 °C, protected from light, and use it within 28 days. Unopened, lyophilized DSIP keeps longest frozen at minus 20 °C. Its reported half-life in circulation is short, so research interest centres on effects that outlast the peptide rather than on the peptide persisting.
DSIP Nasal Spray
For researchers who want DSIP without reconstituting a vial, Chainwell Peptide also supplies a DSIP nasal spray: a 10 mL bottle holding 10mg of DSIP in solution, 1mg per mL, under a white pump actuator. It is the format behind searches for DSIP spray, nasal DSIP and intranasal DSIP, and it suits study designs that call for an intranasal format.
The spray needs no preparation: there is no powder to dissolve and no diluent to measure, and the concentration is fixed at 1mg per mL. Keep the bottle refrigerated at 2 to 8 °C, protected from light, and follow the expiry on the label. Every spray lot is tested by an independent laboratory for identity and purity, and its lot number matches the certificate on our COA lookup page. Like the vials, the DSIP nasal spray is supplied for research use only.
DSIP Vial or Nasal Spray?
| 5mg vial | 10mg vial | Nasal spray | |
|---|---|---|---|
| Form | Lyophilized powder | Lyophilized powder | Solution, 1mg per mL |
| Container | 3 mL glass vial | 3 mL glass vial | 10 mL bottle, pump actuator |
| Preparation | Reconstitute before use | Reconstitute before use | None |
| Concentration | Set by you | Set by you | Fixed at 1mg per mL |
| Suits | First orders, short studies | Ongoing work | Intranasal study designs |
Our recommendation: choose a vial when your work needs DSIP at a concentration or in a vehicle you choose, or when you want the longest shelf life, since lyophilized DSIP keeps longest frozen. Choose the DSIP nasal spray when your research design specifically calls for the intranasal format.
DSIP vs Melatonin and Epitalon
DSIP is often grouped with other sleep-related compounds, but they are different kinds of molecule working in different ways.
| DSIP | Melatonin | Epitalon | |
|---|---|---|---|
| Type | Nine amino acid neuropeptide | Hormone derived from tryptophan, not a peptide | Synthetic four amino acid peptide |
| Associated with | Slow-wave (delta) sleep research | Circadian timing, made by the pineal gland | Pineal gland and ageing research |
| Receptor | No dedicated receptor identified | MT1 and MT2 receptors | Not established |
| Chainwell product | 5mg and 10mg vials | Not stocked | 50mg vial |
DSIP is also studied alongside selank, the tuftsin-derived peptide researched for anxiety-related behaviour. For studies using more than one compound, order separate vials so each can be measured on its own.
DSIP Capsules and Tablets
We supply DSIP as a lyophilized vial or a nasal spray, not as capsules. DSIP is a peptide, and like most peptides it is broken down by digestive enzymes, so there is no established basis for DSIP capsules, pills or tablets. For a format that needs no preparation, see the DSIP nasal spray above.
Lab-Tested DSIP With a COA for Every Lot
Every Chainwell Peptide DSIP lot, vials and nasal spray alike, is sent to an independent laboratory before release. Mass spectrometry confirms the molecular mass matches DSIP, around 849 g/mol, and HPLC measures purity. A lot that does not meet specification is not sold. Check your lot on our COA lookup page, and see our guide on how to read a certificate of analysis.
Buy DSIP Peptide in Australia
Chainwell Peptide supplies DSIP for sale in Australia to laboratories, universities and independent researchers, packed and dispatched from within Australia. Before you buy DSIP online from any supplier, check that the listing states the fill, that the vial carries a lot number, and that the certificate for that lot is available before you pay.
- Same-day dispatch on orders paid before 3pm on a business day.
- Australia-wide delivery to Sydney, Melbourne, Brisbane, Adelaide, Perth, Hobart, Darwin and regional addresses, by standard or express post.
- PayID or bank transfer, with your order number as the payment reference.
- Tracked orders you can follow on our order tracking page.
The current price for each size is shown at the top of this page, with GST included. See our shipping policy for delivery details.
DSIP Specifications
| Compound | DSIP (delta sleep-inducing peptide) |
|---|---|
| Class | Neuropeptide, nonapeptide |
| Sequence | Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu (WAGGDASGE) |
| Molecular formula | C35H48N10O15 |
| Molecular weight | Approximately 848.8 g/mol |
| Formats | 5mg and 10mg lyophilized vials; 10 mL nasal spray, 10mg at 1mg per mL |
| Containers | 3 mL glass vial with teal flip-off cap; 10 mL bottle with pump actuator |
| Identity and purity | Mass spectrometry and HPLC, per lot |
| Diluent | Vials: bacteriostatic water, sold separately. Spray: none needed |
| Storage | Vials: minus 20 °C long term. Spray and reconstituted vials: 2 to 8 °C, protect from light |
| Shipping | Standard or express post, Australia-wide |
Research Use Only
DSIP is not approved by the Therapeutic Goods Administration for any therapeutic use. Chainwell Peptide sells it strictly for laboratory and in vitro research. It is not for human or veterinary use, and we do not provide dosing advice. By ordering you agree to our terms and conditions and research use only statement.
DSIP FAQ
What does DSIP stand for?
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DSIP stands for delta sleep-inducing peptide. It was named in 1977 after researchers reported that it increased delta waves, the slow brain waves of deep sleep, in rabbits. It is a nine amino acid neuropeptide, supplied by Chainwell Peptide in 5mg and 10mg research vials.
What does DSIP do?
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In research, DSIP is studied for effects on slow-wave sleep, stress-related hormone signalling and neurotransmitter systems, mostly in animal models. Human studies have been small with mixed results, and no dedicated DSIP receptor has been identified, so its mechanism remains an open question.
Should I buy DSIP 5mg or 10mg?
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Buy the 5mg vial for a first order, method development or a short study, since it is easiest to use within 28 days of reconstitution. Buy the 10mg vial for ongoing work: it costs less per milligram and keeps repeated work on one lot and certificate.
How do you reconstitute DSIP 5mg?
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Add bacteriostatic water slowly down the inside wall of the vial and swirl gently until clear, without shaking. 1 mL in the 5mg vial gives 5mg per mL. Store the reconstituted vial at 2 to 8 °C, protected from light, and use it within 28 days.
Do you sell DSIP nasal spray?
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Yes. Chainwell Peptide supplies DSIP as a 10 mL nasal spray holding 10mg in solution at 1mg per mL, alongside 5mg and 10mg lyophilized vials. The spray needs no reconstitution; the vials let you set your own concentration. Every format comes with a lot-matched certificate of analysis.
Where can I buy DSIP peptide in Australia?
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You can buy DSIP peptide in Australia from Chainwell Peptide in 5mg and 10mg lyophilized vials or as a 10 mL nasal spray. Every lot carries a lot number matched to an independent certificate of analysis, and orders paid before 3pm on a business day ship the same day by standard or express post.
