What Is 5-Amino-1MQ?
5-Amino-1MQ is the short name for 5-amino-1-methylquinolinium, a small quinolinium compound that selectively inhibits the enzyme nicotinamide N-methyltransferase (NNMT). You will see it written several ways: 5 amino 1mq, 5-amino 1mq, 5 amino 1 mq and 5amino1mq all refer to the same molecule. It is supplied as a salt of the 5-amino-1-methylquinolinium cation.
Although it is sold alongside research peptides and often called the "5 amino 1mq peptide", it is not a peptide at all. There are no amino acids joined by peptide bonds in its structure. It is a small, membrane-permeable molecule, which is exactly why research groups became interested in it: it can reach NNMT inside cells, where the enzyme does its work.
How 5 Amino 1MQ Works: NNMT Inhibition
NNMT transfers a methyl group from S-adenosylmethionine (SAM) to nicotinamide, producing 1-methylnicotinamide. That reaction sits at a crossroads of two pathways researchers care about.
- NAD+ salvage. Nicotinamide is the raw material cells recycle into NAD+. Every molecule NNMT methylates is one less available for NAD+ synthesis.
- Methylation balance. SAM is the cell's main methyl donor. NNMT activity draws on that pool, which links the enzyme to wider methylation capacity.
NNMT is expressed at high levels in adipose tissue and the liver, so its mechanism of action makes 5-Amino-1MQ a tool for studying cellular energy metabolism, NAD+ levels and adipocyte biology. By blocking NNMT, 5 amino 1mq lets a study examine what happens when both nicotinamide and SAM are spared from that reaction.
5-Amino-1MQ Studies and Published Research
Much of the published work on 5-Amino-1MQ comes from research into selective NNMT inhibitors, including a 2018 paper in Biochemical Pharmacology describing membrane-permeable quinolinium inhibitors and their effects in diet-induced obese mice. Later studies have looked at NNMT inhibition alongside diet in mouse models, and at the compound's activity in cell culture.
The research indexed in PubMed is preclinical, carried out in cell culture and animal models. There are no published human trials, and 5-Amino-1MQ is not approved for any therapeutic use. Browse the citations, with links to each paper, in our 5-Amino-1MQ research library.
5-Amino-1MQ vs MOTS-c, SLU-PP-332, NAD+ and AOD-9604
5-Amino-1MQ is often researched alongside other metabolic compounds, and it is frequently confused with them. They work through entirely different mechanisms.
| Compound | Type | Primary target or role |
|---|---|---|
| 5-Amino-1MQ | Small molecule | Inhibits the NNMT enzyme |
| MOTS-c | Mitochondrial-derived peptide | Signalling peptide encoded in mitochondrial DNA |
| SLU-PP-332 | Small molecule | Agonist of the estrogen-related receptors (ERR) |
| NAD+ | Coenzyme | The cofactor itself, rather than a regulator of its supply |
| AOD-9604 | Peptide fragment | Modified fragment of human growth hormone (176 to 191) |
Because 5 amino 1mq affects how much nicotinamide is available for NAD+ recycling, it pairs naturally with NAD+ and mitochondrial compounds in study design. SLU-PP-332 and 5-Amino-1MQ are both small molecules, but one acts on nuclear receptors and the other on an enzyme. The full range sits in metabolic research compounds.
Buy 5-Amino-1MQ in Australia
Chainwell Peptide supplies 5-Amino-1MQ for sale in Australia to laboratories and independent researchers. Before you buy 5 amino 1mq from any supplier, check that the listing states the fill in milligrams, that the vial carries a lot number, and that the certificate of analysis for that lot is available. Ours can be checked on the COA lookup page.
- Same-day dispatch on orders paid before 3pm AEST on a business day.
- Australia-wide delivery by standard or express post, to Sydney, Melbourne, Brisbane, Perth, Adelaide and regional towns.
- PayID or bank transfer, with your order number as the payment reference.
- Tracked orders through our order tracking page.
The current 5 amino 1mq price is shown at the top of this page, with GST included. See our shipping policy for delivery details.
5-Amino-1MQ 50mg Specifications
| Compound | 5-Amino-1MQ (5-amino-1-methylquinolinium) |
|---|---|
| Also written as | 5 amino 1mq, 5-amino 1mq, 5amino1mq |
| Class | Small-molecule NNMT inhibitor (not a peptide) |
| Vial size | 50mg |
| Form | Dry powder in a sealed vial |
| Container | 3 mL clear glass vial, rubber stopper, flip-off cap |
| Label | Product, strength, lot number, expiry, research-use statement |
| Testing | Identity and purity by an independent laboratory, per lot |
| Storage | Cool, dry and dark; refrigerate at 2 to 8 °C once in solution |
| Shipping | Standard or express post, Australia-wide |
5-Amino-1MQ Reconstitution and Storage
The 5-Amino-1MQ vial is supplied dry. Most labs dissolve it in bacteriostatic water, running the diluent down the inside wall of the vial and swirling gently until the powder has fully dissolved. Label the vial with the date, keep it refrigerated and protected from light, and use it within 28 days. Our reconstitution guide and calculator works out concentration for any fill size.
Research Use Only
5-Amino-1MQ is a research compound. It is not approved by the Therapeutic Goods Administration for any therapeutic use, and Chainwell Peptide sells it strictly for laboratory and in vitro research. It is not for human or veterinary use, and we do not provide dosing advice. By ordering you agree to our terms and conditions and research use only statement.
5-Amino-1MQ tools and guides
5-Amino-1MQ FAQ
What is 5 amino 1mq?
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5 amino 1mq (5-Amino-1MQ) is 5-amino-1-methylquinolinium, a small-molecule inhibitor of the enzyme nicotinamide N-methyltransferase (NNMT). It is used in laboratory research into NAD+ metabolism, methylation and adipose tissue biology. Chainwell Peptide supplies it as a 50mg research vial with a lot-matched certificate of analysis.
Is 5-Amino-1MQ a peptide?
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No. Despite often being sold as a peptide, 5-Amino-1MQ is a small quinolinium molecule with no amino acids joined by peptide bonds. It is membrane-permeable, which lets it reach the NNMT enzyme inside cells. It is supplied in a vial like our research peptides and handled in the same way.
How does 5 amino 1mq work?
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5 amino 1mq blocks NNMT, the enzyme that methylates nicotinamide using S-adenosylmethionine. Inhibiting that reaction spares nicotinamide for NAD+ recycling and spares the SAM methyl pool, which is why the compound is used to study NAD+ levels and cellular energy metabolism in cell and animal models.
Has 5-Amino-1MQ been tested in human trials?
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The research on 5-Amino-1MQ indexed in PubMed is preclinical, carried out in cell culture and animal models, and there are no published human trials. It is not approved by the TGA for any therapeutic use. Chainwell Peptide supplies it for laboratory research use only.
Where can I buy 5-Amino-1MQ in Australia?
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You can buy 5-Amino-1MQ in Australia from Chainwell Peptide as a 50mg research vial. Each vial carries a lot number matched to an independent certificate of analysis, and orders paid before 3pm on a business day ship the same day by standard or express post. Payment is by PayID or bank transfer.
